A nurse is caring for a client who received human menopausal gonadotropin

1. World Health Organization. Research on the Menopause, Technical Report Series 670. Geneva: World Health Organization; 1981. [PubMed] [Google Scholar]

2. Soules MR, Sherman S, Parrott E, Rebar R, Santoro N, Utian W, et al. Executive summary: Stages of Reproductive Aging Workshop (STRAW) Climacteric. 2001;4:267–72. [PubMed] [Google Scholar]

3. Diczfalusy E. The Climacteric in Perspective. In: Notelovitz H, Van Keep PA, editors. Lancaster: MTP Press; 1984. pp. 1–15. [Google Scholar]

4. Islam MR, Gartoulla P, Bell RJ, Fradkin P, Davis SR. Prevalence of menopausal symptoms in Asian midlife women: A systematic review. Climacteric. 2015;18:157–76. [PubMed] [Google Scholar]

5. Gold EB, Sternfeld B, Kelsey JL, Brown C, Mouton C, Reame N, et al. Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40-55 years of age. Am J Epidemiol. 2000;152:463–73. [PubMed] [Google Scholar]

6. Hill K. The demography of menopause. Maturitas. 1996;23:113–27. [PubMed] [Google Scholar]

7. [Last accessed on 2021 Feb 10]; Available from: https://www.macrotrends.net/countries/BGD/bangladesh/population . [Google Scholar]

8. [Last accessed on 2021 Feb 20]; Available from: https://www.worldometers.info/world-population/bangladesh-population/ [Google Scholar]

9. Ahmed K, Jahan P, Nadia I, Ahmed F, Abdullah-Al-Emran Assessment of Menopausal Symptoms among Early and Late Menopausal Midlife Bangladeshi Women and Their Impact on the Quality of Life. J Menopausal Med. 2016;22:39–46. doi: 10.6118/jmm.2016.22.1.39. [PMC free article] [PubMed] [Google Scholar]

10. Mohammad Z, Rahman M, Akter T, Akhter T, Ahmed A, Shovon MA, et al. Hypertension prevalence and its trend in Bangladesh: Evidence from a systematic review and meta-analysis. Clin Hypertens. 2020;26:10. [PMC free article] [PubMed] [Google Scholar]

11. Akhtar S, Nasir JA, Sarwar A, Nasr N, Javed A, Majeed R, et al. Prevalence of diabetes and pre-diabetes in Bangladesh: A systematic review and meta-analysis. BMJ Open. 2020;10:e036086. [PMC free article] [PubMed] [Google Scholar]

12. Begum RA, Ali L, Akter J, Takahashi O, Fukui T, Rahman M. Osteopenia and osteoporosis among 16-65 year old women attending outpatient clinics. J Community Health. 2014;39:1071–6. [PubMed] [Google Scholar]

13. Chandrakanth Are ,Cancer on the Global Stage: Incidence and Cancer-Related Mortality in Bangladesh; The ASCO Post; February 25. 2017 [Google Scholar]

14. [Last assecced on 2021 Feb 20];World Health Statistics: Life Expectancy and Healthy Life. Available from: https://www.worldometers.info/demographics . [Google Scholar]

15. [Last accessed on 2021 Feb 20]; Available from: https://www.facebook.com/133972516617260/videos/313927853627095 . [Google Scholar]

16. Wangdi K, Jamtsho T. Prevalence and predisposing factors for self-reported hypertension in Bhutanese adults. Nepal J Epidemiol. 2020;10:830–40. [PMC free article] [PubMed] [Google Scholar]

17. [Last accessed on 2021 Feb 20]; Available from: https://cdn.who.int/media/docs/default-source/searo/ncd/noncommunicable-disease-risk-factors-bhutan-stepssurvey-report-2019.pdf . [Google Scholar]

18. Giri BR, Sharma KP, Chapagai RN, Palzom D. Diabetes and hypertension in urban Bhutanese men and women. Indian J Community Med. 2013;38:138–43. [PMC free article] [PubMed] [Google Scholar]

19. [Last accessed on 2021 Feb 10];Globocan. 2020 Available from: https://gco.iarc.fr/today/data/factsheets/populations/64-bhutan-fact-sheets.pdf . [Google Scholar]

20. [Last accessed on 2021 Jul 18]; Available from: https://www.worldometers.info/world-population/north-korea-population/ [Google Scholar]

21. Park CY, Lim JY, Park HY. Age at natural menopause in Koreans: Secular trends and influences thereon. Menopause. 2018;25:423–9. [PubMed] [Google Scholar]

22. Kim HC, Cho MC Korean Society Hypertension (KSH); Hypertension Epidemiology Research Working Group. Korea hypertension fact sheet 2018. Clin Hypertens. 2018;24:13. [PMC free article] [PubMed] [Google Scholar]

23. Roh E, Ko SH, Kwon HS, Kim NH, Kim JH, Kim CS, et al. Prevalence and management of dyslipidemia in Korea: Korea national health and nutrition examination survey during 1998 to 2010. Diabetes Metab J. 2013;37:433–49. [PMC free article] [PubMed] [Google Scholar]

24. Kim SM, Lee JS, Lee J, Na JK, Han JH, Yoon DK, et al. Prevalence of diabetes and impaired fasting glucose in Korea. Diabetes Care. 2006;29:226–31. [PubMed] [Google Scholar]

25. Choi YJ, Oh HJ, Kim DJ, Lee Y, Chung YS. The prevalence of osteoporosis in Korean adults aged 50 years or older and the higher diagnosis rates in women who were beneficiaries of a national screening program: The Korea National Health and Nutrition Examination Survey 2008-2009. J Bone Miner Res. 2012;27:1879–86. [PubMed] [Google Scholar]

26. [Last accessed on 2021 Feb 10];GLOBOCAN 2020. Available from: https://gco.iarc.fr/today/data/factsheets/populations/410-korea-republic-of-fact-sheets.pdf . [Google Scholar]

27. [Last accessed on 2021 Feb 10]; Available from: https://www.worldometers.info/world-population/india-population/ [Google Scholar]

28. United Nations, Department of Economic and Social Affairs, Population Division (2019). World Population Prospects 2019: Data Booket. ST/ESA/SER.A/424 [Google Scholar]

29. Meeta M, Digumarti L, Agarwal N, Vaze N, Shah R, Malik S. Clinical practice guidelines on menopause: *An executive summary and recommendations: Indian menopause society 2019-2020. J Midlife Health. 2020;11:55–95. [PMC free article] [PubMed] [Google Scholar]

30. Sivasubramanian R, Geevar Z, Kartik G, Shivkumar Rao J, Mohanan PP, Venugopal K, et al. Prevalence of hypertension among Indian adults: Results from the great India blood pressure survey. Indian Heart J. 2019;71:309–13. [PMC free article] [PubMed] [Google Scholar]

31. Guptha S, Gupta R, Deedwania P, Bhansali A, Maheshwari A, Gupta A, et al. Cholesterol lipoproteins and prevalence of dyslipidemias in urban Asian Indians: A cross sectional study. Indian Heart J. 2014;66:280–8. [PMC free article] [PubMed] [Google Scholar]

32. Ranasinghe P, Jayawardena R, Gamage N, Sivanandam N, Misra A. Prevalence and trends of the diabetes epidemic in urban and rural India: A pooled systematic review and meta-analysis of 1.7 million adults. Ann Epidemiol. 2021;58:128–48. [PubMed] [Google Scholar]

33. Meeta M, Harinarayan CV, Marwah R, Sahay R, Kalra S, Babhulkar S. Clinical practice guidelines on postmenopausal osteoporosis: *An executive summary and recommendations - Update 2019-2020. J Midlife Health. 2020;11:96–112. [PMC free article] [PubMed] [Google Scholar]

34. Babhulkar S, Seth S. Prevalence of osteoporosis in India: An observation of 31238 adults. International Journal of Research in Orthopaedics. 2021;7:362–8. doi: https://dx.doi.org/10.18203/issn.2455-4510.IntJResOrthop20210630. [Google Scholar]

35. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–49. [PubMed] [Google Scholar]

36. [Last accessed on 2021 Feb 20]; Available from: https://www.worldometers.info/world-population/indonesia-population/ [Google Scholar]

37. [Last accessed on 2021 Feb 10, Last accessed on 2021 Feb 20];First Consensus Meeting on Menopause in the East Asian Region Menopause - Country-specific information of Indonesia. Available from: https://www.gfmer.ch/Books/bookmp/173.htm . [Google Scholar]

38. Peltzer K, Pengpid S. The prevalence and social determinants of hypertension among adults in Indonesia: A crosssectional population-based national survey. Int J Hypertens 2018. 2018 5610725. [PMC free article] [PubMed] [Google Scholar]

39. [Last accessed on 2021 Feb 20];World Health Organization Global Health Observatory Data Repository. 2013 Available from: https://apps.who.int/gho/data/view.main.2467?lang=en . [Google Scholar]

40. World Health Organization ata/view.maCountry Profiles. 2016 Available from: https://www.who.int/diabetes/country-profiles/idn_en.pdf . [Google Scholar]

41. Meiyanti M. Epidemiology of osteoporosis in postmenopausal women aged 47 to 60 years. Univers Med. 2010;29:169–76. [Google Scholar]

42. [Last accessed on 2021 Feb 10];Globocan. Available from: https://gco.iarc.fr/today/data/factsheets/populations/360-indonesia-fact-sheets.pdf . [Google Scholar]

43. [Last accessed on 2021 Feb 10]; Available from: https://www.worldometers.info/world-population/maldives-population/ [Google Scholar]

44. Aboobakur M, Latheef A, Mohamed AJ, Moosa S, Pandey RM, Krishnan A, et al. Surveillance for non-communicable disease risk factors in Maldives: Results from the first STEPS survey in Male. Int J Public Health. 2010;55:489–96. [PubMed] [Google Scholar]

45. Jackson AM. Uncovering the “Skeleton in the Closet”: The Issue of Bone and Joint Disorders in the Maldives and the Opportunities for Primary Prevention and Health Promotion. J Primary Prevent. 2006;27:409–31. [PubMed] [Google Scholar]

46. [Last accessed on 2021 Feb 10];Globocan 2020. Available from: https://gco.iarc.fr/today/data/factsheets/populations/462-maldives-fact-sheets.pdf . [Google Scholar]

47. [Last accessed on 2021 Feb 10]; Available from: https://www.worldometers.info/world-population/myanmar-population/ [Google Scholar]

48. Bjertness MB, Htet AS, Meyer HE, Htike MM, Zaw KK, Oo WM, et al. Prevalence and determinants of hypertension in Myanmar - A nationwide cross-sectional study. BMC Public Health. 2016;16:590. [PMC free article] [PubMed] [Google Scholar]

49. Htet AS, Kjdal MK, Aung WP, Moe Myint AN, Aye WT, Wai MM, et al. Lipid profiles and determinants of total cholesterol and hypercholesterolaemia among 25-74 year-old urban and rural citizens of the Yangon Region, Myanmar: A cross-sectional study. BMJ Open. 2017;7:e017465. [PMC free article] [PubMed] [Google Scholar]

50. Latt TS, Zaw KK, Ko K, Hlaing MM, Ohnmar M, Oo ES, et al. Measurement of diabetes, prediabetes and their associated risk factors in Myanmar 2014. Diabetes Metab Syndr Obes. 2019;12:291–8. [PMC free article] [PubMed] [Google Scholar]

51. Osteoporosis, Prevalence and Risk by Chit Soe, Aye Aye Khaing and Pandora Aung Gyi. (Myanmar Health Research Congress, 2004) Available from: https://www.slideshare.net/MyanmarRheumatology/op-cml . [Google Scholar]

52. Globocan 2020. Available from: https://gco.iarc.fr/today/data/factsheets/populations/104-myanmar-fact-sheets.pdf . [Google Scholar]

53. Available from: https://www.worldometers.info/world-population/nepal-population/ [Google Scholar]

54. [Last accessed on 2021 Jul 20];Nepal Life Expectancy 1950-2021. Data Source: United Nations - World Population Prospects. Available from: https://www.macrotrends.net/countries/NPL/nepal/life-expectancy . [Google Scholar]

55. Rajbhandari S, Subedi RK, Dangal G, Phuyal A, Vaidya A, Karki A, et al. Menopausal Health Status of Nepalese Women. JNMA J Nepal Med Assoc. 2017;56:107–11. [PubMed] [Google Scholar]

56. Huang Y, Guo P, Karmacharya BM, Seeruttun SR, Xu DR, Hao Y. Prevalence of hypertension and prehypertension in Nepal: A systematic review and meta-analysis. Glob Health Res Policy. 2019;4:11. [PMC free article] [PubMed] [Google Scholar]

57. Pokharel DR, Khadka D, Sigdel M, Yadav NK, Acharya S, Kafle R, et al. Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes. BMC Res Notes. 2017;10:146. [PMC free article] [PubMed] [Google Scholar]

58. Gyawali B, Sharma R, Neupane D, Mishra SR, van Teijlingen E, Kallestrup P. Prevalence of type 2 diabetes in Nepal: A systematic review and meta-analysis from 2000 to 2014. Glob Health Action. 2015;8:29088. [PMC free article] [PubMed] [Google Scholar]

59. Chaudhary NK, Timilsena MN, Sunuwar DR, Pradhan PM, Sangroula RK. Association of lifestyle and food consumption with bone mineral density among people aged 50 years and above attending the hospitals of Kathmandu, Nepal. J Osteoporos 2019. 2019 1536394. [PMC free article] [PubMed] [Google Scholar]

60. [Last accessed on 2021 Feb 10];Globocan 2020. Available from: https://gco.iarc.fr/today/data/factsheets/populations/524-nepal-fact-sheets.pdf . [Google Scholar]

61. [Last accessed on 2021 Feb 10]; Available from: https://www.worldometers.info/world-population/sri-lanka-population/ [Google Scholar]

62. [Last accessed on 2021 Feb 10];Annual Health Statistics of Sri Lanka 2019. Available from: http://www.health.gov.lk/moh_final/english/public/elfinder/files/publications/AHB/AHS%202019.pdf . [Google Scholar]

63. [Last accessed on 2021 Feb 10];Family Planning Association of Sri Lanka. Available from: http://www.fpasrilanka.org/content/menopause#:~:text=In%20Sri%20Lanka%2C%20the%20age%20of%20menopause%20happens%20around%2051%20years . [Google Scholar]

64. [Last accessed on 2021 Feb 10];A Cross-Sectional Population Based National Survey. Available from: https://pubmed.ncbi.nlm.nih.gov/24433043/ [Google Scholar]

65. Katulanda P, Dissanayake HA, De Silva SD, Katulanda GW, Liyanage IK, Constantine GR, et al. Prevalence, patterns, and associations of dyslipidemia among Sri Lankan adults-Sri Lanka Diabetes and Cardiovascular Study in 2005-2006. J Clin Lipidol. 2018;12:447–54. [PubMed] [Google Scholar]

66. Somasundaram P, Ranathunga I, Gunawardana K, Ediriweera DS. High prevalence of Diabetes Mellitus in Sri Lankan Urban Population - Data from Colombo Urban Study. [Last accessed on 2021 Feb 10]; https://sjdem.sljol.info/articles/10.4038/sjdem.v9i2.7393/galley/5804/download. [Google Scholar]

67. Karunanayake AL, Pinidiyapathirage MJ, Wickremasinghe AR. Prevalence and predictors of osteoporosis in an urban Sri Lankan population. Int J Rheum Dis. 2010;13:385–90. [PubMed] [Google Scholar]

68. [Last accessed on 2021 Feb 10];Globocan 2020. Available from: https://gco.iarc.fr/today/data/factsheets/populations/144-sri-lanka-fact-sheets.pdf . [Google Scholar]

69. [Last accessed on 2021 Feb 10]; Available from: https://www.worldometers.info/world-population/thailand-population . [Google Scholar]

70. Chompootweep S, Tankeyoon M, Yamarat K, Poomsuwan P, Dusitsin N. The menopausal age and climacteric complaints in Thai women in Bangkok. Maturitas. 1993;17:63–71. [PubMed] [Google Scholar]

71. Sakboonyarat B, Rangsin R, Kantiwong A, Mungthin M. Prevalence and associated factors of uncontrolled hypertension among hypertensive patients: A nation-wide survey in Thailand. BMC Res Notes. 2019;12:380. [PMC free article] [PubMed] [Google Scholar]

72. Aekplakorn W, Taneepanichskul S, Kessomboon P, Chongsuvivatwong V, Putwatana P, Sritara P, et al. Prevalence of dyslipidemia and management in the Thai Population, National Health Examination Survey IV, 2009. J Lipids 2014. 2014 249584. [PMC free article] [PubMed] [Google Scholar]

73. Aekplakorn W, Stolk RP, Neal B, Suriyawongpaisal P, Chongsuvivatwong V, Cheepudomwit S, et al. The prevalence and management of diabetes in Thai adults: The international collaborative study of cardiovascular disease in Asia. Diabetes Care. 2003;26:2758–63. [PubMed] [Google Scholar]

74. Pongchaiyakul C, Songpattanasilp T, Taechakraichana N. Burden of osteoporosis in Thailand. J Med Assoc Thai. 2008;91:261–7. [PubMed] [Google Scholar]

75. [Last accessed on 2021 Feb 10];Globocan 2020. Available from: https://gco.iarc.fr/today/data/factsheets/populations/764-thailand-fact-sheets.pdf . [Google Scholar]

76. [Last accessed on 2021 Feb 10]; Available from: https://www.worldometers.info/world-population/timor-leste-population . [Google Scholar]

77. Boulet MJ, Oddens BJ, Lehert P, Vemer HM, Visser A. Climacteric and menopause in seven South-east Asian countries. Maturitas. 1994;19:157–76. [PubMed] [Google Scholar]

78. [Last accessed on 2021 Feb 10]; Available from: https://www.who.int/ncds/surveillance/steps/tls_en.pdf?ua=1 . [Google Scholar]

79. [Last accessed on 2021 Feb 10];National Survey for Noncommunicable Disease Risk Factors and Injuries Using WHO STEPS Approach in Timor-Leste - 2014. Available from: https://www.who.int/ncds/surveillance/steps/Timor-Leste_2014_STEPS_Report.pdf . [Google Scholar]

80. Dawkins RC, Oliver GF, Sharma M, Pinto BM, Jeronimo B, Pereira B, et al. An estimation of the prevalence of diabetes mellitus and diabetic retinopathy in adults in Timor-Leste. BMC Res Notes. 2015;8:249. [PMC free article] [PubMed] [Google Scholar]

81. [Last accessed on 2021 Feb 10];Globobcan 2020. Available from: https://gco.iarc.fr/today/data/factsheets/populations/626-timor-leste-fact-sheets.pdf . [Google Scholar]


Page 2

Epidemiology of menopause in the South East Asia Region

CountryPopulationLife expectancy (years)Mean age at menopause (years)Prevalence of comorbidities
HT (%)DP (%)DM (%)PMO (%)CC (%)
Bangladesh166,440,970[7]74.4[8]48-50[9]20[10]717.8[11]41.8[12]Breast[13]
Bhutan780,696[14]73.3[14]49.2[15]17.4[16]11[17]7.7[18]-Cervix[19]
DPR Korea25,896,523[20]72.89[20]49.3[21]22.9[22]60.4[23]7.5[24]35.5[25]Breast[26]
India1,394,197,982[27]70.3[28]46.7[29]45.4[30]24.9[31]U-19 R-15[32]16-65[33] 33.1[34]Breast[35]
Indonesia276,604,339[36]732.3[36]50.2[37]35.4[38]38.2[39]7.3[40]20.2-30[41]Breast[42]
Maldives550,433[43]79.89[43]NA32.9[44]54.9[44]4.7[44]15[45]Breast[46]
Myanmar54,795,718[47]67.78[47]NA29.8[48]50.7[49]9.2[50]53.8[51]Cervix[52]
Nepal29,681,109[53]71.17[54]48.7[55]U-28.4 R-24.4[56]44.7[57]8.4%[58]26-37.2[59]Cervix[60]
Sri Lanka21,507,827[61]78.6[62]51[63]23.8[64]77.4[65]27.6[66]27[67]Breast[68]
Thailand69,983,923[69]77.74[69]49.5[70]24.6[71]66.5[72]9.6[73]19.8[74]Breast[75]
Timor Leste1,345,626[76]70.18[76]51.02[77]39.5[78]25.5[79]15[80]NABreast[81]