Research suggests that healthcare workers (HCWs) who handle hazardous drugs (HDs) may experience acute effects such as skin rashes or more chronic effects including adverse reproductive events and malignancy. Show Consequently, government and regulatory agencies such as the National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, and Occupational Safety and Health Administration (OSHA) issue recommendations for safe handling, including the use of personal protective equipment (PPE). Adherence to these recommendations minimizes the risk of unintended exposure and harmful side effects. Because there is no safe level of exposure to HDs and no reliable method of monitoring work-related exposure, strict adherence to safety standards is essential. What ONS RecommendsBased on OSHA and NIOSH standards, ONS recommends a hierarchy of controls to ensure safe practice and reduce opportunity for exposure. These include use of biologic safety cabinets and closed-system transfer devices (CSTDs), clearly defined policies and procedures, and staff training with competency demonstration. ONS also recommends PPE, which is known to protect HCWs against exposure to HDs. Follow these best practices for safety:
Surface contamination is consistently found in studies testing for the presence of traces of hazardous agents, as well as the body fluids of those who’ve received these agents. Therefore, PPE recommendations also apply to nursing assistants, environmental staff, and others who may have contact with patients receiving HDs. Safe handling precautions related to newer, nonchemotherapy agents, including biotherapy, targeted agents, and immunotherapy, are drug specific. Limited research is available on the hazardous potential of investigational drugs and those new to market. Collaboration with infection control or biologic safety departments may assist when developing policies and procedures regarding these agents until more is known about long-term effects. Each care site should have an ongoing process for drug evaluation through current literature, product information, and safety data sheets. HD precautions are indicated when drugs display traits of carcinogenicity, teratogenicity, genotoxicity, reproductive toxicity, or organ toxicity at low doses, as well as those with a mechanism of action that indicates a hazardous risk. USP Chapter 800The U.S. Pharmacopeial Convention document, Hazardous Drugs—Handling in Healthcare Settings, commonly referred to as Chapter 800, has recommendations for the use of PPE that align with ONS’s. Chapter 800 also outlines additional components, such as use of CSTDs, hierarchy of control requirements, and HCW training and communication. Reviewing practice implications associated with Chapter 800 may be beneficial to ensure compliance with all standards surrounding safe handling. ONS offers a variety of resources to help implement and provide rationale for safe handling, including many of our publications, online courses, and position statements. This is also a frequently discussed topic on the ONS Communities discussion boards. ONS’s Safe Handling of Hazardous Drugs walks practitioners and administrators through various research and practice recommendations. Adherence to these recommendations is imperative as research continues to identify traces of hazardous agents on surfaces and HCWs’ gloves and gowns, indicating that the risk for exposure is present.
Chemotherapy drugs are considered to be hazardous to people who handle them or come into contact with them. For patients, this means the drugs are strong enough to damage or kill cancer cells. But this also means the drugs can be a concern for others who might be exposed to them. This is why there are safety rules and recommendations for people who handle chemo drugs. It's important to know that not all medicines and drugs to treat cancer work the same way or have the same safety precautions. The information below describes some safety concerns of traditional or standard chemotherapy. There are also other drugs that are used to treat cancer in different ways, including targeted therapy, hormone therapy, and immunotherapy. Precautions the cancer care team will takeYou may notice special clothing and protective equipment being worn by the nurses and other members of your cancer care team. Pharmacists and nurses who prepare chemo drugs use a special type of pharmacy that must meet certain regulations. And nurses and others who give your chemo and help take care of you afterwards wear protective clothing, such as 2 pairs of special gloves and a gown, and sometimes goggles or a face shield. If you're getting IV chemo, there might be a disposable pad under the infusion tubing to protect the surface of the bed or chair. Special precautions when taking chemo by mouthOral chemo, or chemo you take by mouth and swallow, is usually taken at home. These drugs are as strong as other forms of chemo, and many are considered hazardous. There are usually special precautions for storing and handling oral chemo drugs. You might be told to be careful not to let others come into contact with it or your body fluids while taking it and for a time after taking it. Sometimes you need to wear gloves when touching the pills or capsules. Some drugs have to be kept in the bottle or box they came in. And some drugs and the packages they come in need to be disposed of in a certain way. Some might have to be taken back to the drug store to be thrown away safely. If you are taking an oral chemo drug, talk to your cancer care team about any special precautions needed at home. To learn more, see Getting Oral or Topical Chemotherapy. Keeping family and friends safeThere are certain safety precautions that might be needed during and after getting chemo. Unless your health care team tells you differently, you can usually be around family and friends during the weeks and months you're getting chemo. On treatment days, family and friends can often come with you. However, some treatment centers only allow patients in the infusion area and visitors may need to stay in the waiting room. You are the only person who should be exposed to the chemo you are getting, but it can be irritating if it gets on your skin. Any spilled IV chemo, any powder or dust from a pill or capsule, or any liquid from oral or other kinds of chemo can be hazardous to others if they are around it. There are many things you can do during and after chemo to keep yourself and your loved ones from being affected by the chemo drugs while your body is getting rid of them. Again, talk to your cancer care team about if these or any other precautions should be followed. What to do during – and for 48 to 72 hours after – chemo:It generally takes about 48 to 72 hours for your body to break down and/or get rid of most chemo drugs. But it's important to know that each chemo drug is excreted or passed through the body a bit differently. Talk to your doctor or nurse about how the chemo you are getting is passed and what body fluids may be affected by chemo. Some drugs take longer to leave your body. Most of the drug waste comes out in your body fluids, such as urine, stool, tears, sweat, and vomit. The drug waste is also in your blood, and may be in other body fluids such as fluids from semen and the vagina. When chemo drugs or their waste are outside your body, they can harm or irritate skin. Other people and pets could be exposed to the drug waste for a few days if they come into contact with any of your body fluids. Here are things you can do to help keep your family, visitors, and pets safe during this time:
Preventing infectionsMost chemo drugs make you less able to fight infection, but there are ways you can do your best to avoid getting an infection. To learn more, see Infections. |