Why is buclizine an effective antiemetic?

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Updated strategy, run July 2010

1. exp gastroenteritis/ 2. gastroenteritis.tw. 3. exp Rotavirus Infections/ 4. exp Norwalk virus/ or norwalk virus.tw. 5. exp vomiting/ 6. vomit$.tw. 7. exp Diarrhea, Infantile/ 8. diarrhea.tw. 9. diarrhoea.tw. 10. exp dehydration/ 11. dehydrat$.tw. 12. or/1‐11 13. exp Antiemetics/ or antiemetic$.tw. 14. exp Dopamine Antagonists/ 15. (dopamin$ adj2 antagonist$).tw. 16. (Chlorpromazine or aminazine or chloractil or chlordelazine or contomin or dozine or fenactil or largactil or ormazine or propaphenin or thorazine).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 17. (droperidol or dehidrobenzperidol or droleptan or inapsine or Dridol).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 18. (domperidon$ or domidon or evoxin or gastrocure or motilium or motillium or motinorm or costi or nauzelin).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 19. (metoclopramide or cerucal or clopra or degan or gastrese or gastrobid continus or gastroflux or gastromax or maxolon or maxeran or metaclopramide or metozolv or metramid or migravess or mygdalon or octamide or parmid or primperan or pylomid or reglan or reliveran or rimetin).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 20. (haloperidol or dozic or Aloperidin or Bioperidolo or Brotopon Duraperidol or fortunan or haldol or kentace or Einalon or Eukystol, or Halosten or Keselan or Linton or Peluces or Serenase or Sigaperidol or serenace).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 21. (prochlorperazine or buccastem or compazine or compro or emezine or procot or proziere or Phenotil or stemetil or Stemzine).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 22. (promethazine or Avomine or adgan or aler‐dryl or aler‐tab or aller‐dryl topical or allergia or allermax or altaryl or anergan or antihist or antinaus or antituss or atosil or banaril or banophen or beldin or belix or ben tann or benadryl or benahist or bendylate or benekraft or benzhydramine or bromanate or calm‐aid or derma‐pax or dimedrol or dimine or diphen or diphenadryl or diphenhist or diphenhydramine or diphenmax or diphenyl or diphergan or diprazin or dormarex or dytan or dytuss or eldadryl or Fargan or Farganesse or genahist or hydramine or hyrexin or isopromethazine or Lergigan or medinex or nervine or nightcalm or nu‐med or nytol or pardryl or paxidorm or pediacare or pentazine or phenadoz or phenazine or phendry or phenergan or phenerzine or phenoject or phensedyl or phenylbenzene or pipolphen or pro‐med or proazamine or progan or promacot or promet or prometazin or promethegan or prorex or prothazin or Prothiazine or provigan or pyrethia or quenalin or remsed or Romergan or Receptozine or rumergan or siladryl or siladyl or silphen or sleep tab* or sleep‐ettes or sleep‐eze or sleepia or sleepinal or sominex or somnicaps or trux‐adryl or tusstat or twilite or uni‐hist or uni‐tann or unisom sleepgels or unisom sleepmelts or valu‐dryl or wehdryl or zipan).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 23. exp Serotonin Antagonists/ 24. (serotonin adj2 antagonist$).tw. 25. (dolasetron or anzemet).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 26. (granisetron or granisol or kytril or sancuso).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 27. (Ondansetron or zensana or zofran).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 28. (tropisetron or Navoban or Setrovel).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 29. exp Cholinergic Antagonists/ or anticholinergic agent$.tw. 30. (scopolamine or atrochin or boroscopol or buscapine or buscolysin or buscopan or butylscopolamine or butylscopolammonium bromide or epoxytropine tropate or hyocine hydrobromide or hyoscinbutylbromide or hyoscine or kwell or levo‐duboisine or maldemar or scoburen or scopace or scopoderm or scopolaminebutylbromide or scopolaminum hydrobromicum or scopolan or transderm or transderm‐scop or travacalm or vorigeno).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 31. exp Histamine Antagonists/ 32. buclizine.tw. 33. cyclizine.tw. 34. (dimenhydrinate or antimo or aviomarin or biodramina or cinfamar or contramareo or dimen heumann or dimen lichtenstein or dimetabs or dinate or diphenhydramine theoclate or dramamine or dramin or Driminate or dramanate or dramoject or dymenate or gravol or Gravamin or marmine or nausicalm or reisegold or reisetabletten ratiopharm or reisetabletten stada or rodovan or rubiemen or superpep or travel‐eze or travel‐wise or triptone or uni‐calm or Vertirosan or Viabom or vomex or vomacur or vomisin or wehamine).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 35. (Trimethobenzamide or barogan or benzacot or tebamide or ticon or tigan).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 36. (meclizine or agyrax or antivert or bonamine or bonikraft or bonine or chiclida or histametizyn or meclicot or meclozine or medivert or parachloramine or ruvertm or univert).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 37. exp Benzodiazepines/ 38. (lorazepam or almazine or apolorazepam or ativan or donix or durazolam or idalprem or laubeel or lorazep or novolorazem or nuloraz or orfidal wyeth or sedicepan or sinestron or somagerol or tolid or temesta).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 39. exp Adrenal Cortex Hormones/ or corticosteroids.tw. 40. (dexamethasone or aacidexam or adexone or adrenocot or aeroseb or aknichthol dexa or alba‐dex or alin or ambene or amplidermis or anemul mono or antimicotico or aquapred or auricularum or auxiloson or azona or baycadron or baycuten or cebedex or corson or cortastat or cortidex or cortidexason or cortisumman or corto‐tavegil or dalalone or deca or decacort or decaderm or decadron or decalix or decasone or decaspray or dectancyl or deenar or dekasol or deronil or desamethasone or desameton or dexa‐mamallet or dexa‐rhinosan or dexa‐scheroson or dexa‐sine or dexacen or dexacort phosphate or dexacort* or dexafarma or dexafluorene or dexair or dexaject or dexalocal or dexamecortin or dexameth or dexamethasonedisodium phosphate or dexamethasonum or dexamonozon or dexapos or dexasol or dexasone or dexinoral or dexium or dexpak or dinormon or doxiproct or fluorodelta or fortecortin or gammacorten or hexadecadrol or hexadrol or lokalison or loverine or maxidex or medidex or metazone or methylfluorprednisolone or millicorten or mymethasone or ocasa or ocu‐dex or oradexon or orgadrone or otomize or ozurdex or predni or primethasone or robadex or soludecadron or solurex or spersadex or trabit or visumetazone or voren).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 41. (methylprednisolone or a‐methapred or adlone or ak‐pred or ak‐tate or aprednislon or articulose or asmacortone or balpred or blephamide liquifilm or bubbli‐pred or caberdelta or capsoid or codelson or cortalone or corti‐clyss or cortimed or cortisolone or cotolone or cryosolona or decaprednil or decortin or delta‐cortef or delta‐diona or delta‐phoricol or deltacortilen or deltacortril or deltahydrocortisone or deltasolone or deltastab or deltidrosol or depmedalone or depo moderin or depo‐medrol or depo‐nisolone or depoject or depopred or dhasolone or di‐adreson‐f or diopred or dontisolon or duralone or duro cort or econopred or emmetipi or esametone or estilsona or firmacort or fisopred or flo‐pred or frisolona or gupisone or hexacortone or hostacortin or hydeltra or hydeltrasol or hydrocortancyl or inf‐oph or inflamase or inflanefran or isolone or key‐pred or klismacort or kuhlprednon or lenisolone or lepi‐cortinolo or locaseptil or longiprednil or med‐jec or medicort or medlone or medrate or medrol or medrone or mega‐star or meprdl or meprolone or metacortandralone or methacort or methylcotol or methylcotolone or methylone or methylpred or methylprednisolonum or meti derm or meticortelone or metilbetasone solubile or metipred or metrocort or metypresol or metysolon or millipred or ocu‐pred or omnipred or ophtho‐tate or opredsone or orapred or panafcortelone or pediapred or poly‐pred liquifilm or polypred or precortalon aquosum or precortisyl or pred‐clysma or pred‐ject or pred‐phosphate or predacorten or predair or predaject or predalone or predate or predcor or predeltilone or predenema or predfoam or predicort or predmix or prednabene or prednefrin or predni‐coelin or predni or predni‐helvacort or predni‐m‐tablinen or predni‐pos or prednicortelone or prednihexal or prednilen or predniocil or prednisol or prednisolone or prednoral or predonine or predsol or prelone or pri‐cortin or pri‐methylate or pricortin or radilem or sano‐drol or scherisolone‐kristall or sieropresol or solpredone or solu moderin or solu‐medrol or sterane or stintisone or summicort or urbason or urbasonsoluble or veripred or wyacort).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 42. exp cannabinoids/ 43. cannabinoid$.tw. 44. (cannador or charas or ganja* or hashish or hemp or cannabis or marihuana or marijuana).tw. 45. (marinol or dronabinol or tetrahydrocannabinol).mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 46. or/13‐45 47. exp infant/ or infan$.tw. 48. exp child/ or child$.tw. 49. exp Child, Preschool/ 50. neonat$.tw. 51. pediatric$.mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 52. paediatric$.mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] 53. juvenile$.tw. 54. exp adolescent/ or adolescen$.tw. 55. or/47‐54 56. 12 and 46 and 55 57. limit 56 to yr="2008 ‐Current"

Updated strategy, run July 2010

1. randomized controlled trial.pt. 2. controlled clinical trial.pt. 3. randomized.ab. 4. placebo.ab. 5. drug therapy.fs. 6. randomly.ab. 7. trial.ab. 8. groups.ab. 9. or/1‐8 10. exp animals/ not humans.sh. 11. 9 not 10 12. exp gastroenteritis/ 13. gastroenteritis.tw. 14. exp Rotavirus Infections/ 15. exp Norwalk virus/ or norwalk virus.tw. 16. exp vomiting/ 17. vomit$.tw. 18. exp Diarrhea, Infantile/ 19. diarrhea.tw. 20. diarrhoea.tw. 21. exp dehydration/ 22. dehydrat$.tw. 23. or/12‐22 24. exp Antiemetics/ or antiemetic$.tw. 25. exp Dopamine Antagonists/ 26. (dopamin$ adj2 antagonist$).tw. 27. (Chlorpromazine or aminazine or chloractil or chlordelazine or contomin or dozine or fenactil or largactil or ormazine or propaphenin or thorazine).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

28. (droperidol or dehidrobenzperidol or droleptan or inapsine or Dridol).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

29. (domperidon$ or domidon or evoxin or gastrocure or motilium or motillium or motinorm or costi or nauzelin).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

30. (metoclopramide or cerucal or clopra or degan or gastrese or gastrobid continus or gastroflux or gastromax or maxolon or maxeran or metaclopramide or metozolv or metramid or migravess or mygdalon or octamide or parmid or primperan or pylomid or reglan or reliveran or rimetin).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

31. (haloperidol or dozic or Aloperidin or Bioperidolo or Brotopon Duraperidol or fortunan or haldol or kentace or Einalon or Eukystol, or Halosten or Keselan or Linton or Peluces or Serenase or Sigaperidol or serenace).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

32. (prochlorperazine or buccastem or compazine or compro or emezine or procot or proziere or Phenotil or stemetil or Stemzine).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

33. (promethazine or Avomine or adgan or aler‐dryl or aler‐tab or aller‐dryl topical or allergia or allermax or altaryl or anergan or antihist or antinaus or antituss or atosil or banaril or banophen or beldin or belix or ben tann or benadryl or benahist or bendylate or benekraft or benzhydramine or bromanate or calm‐aid or derma‐pax or dimedrol or dimine or diphen or diphenadryl or diphenhist or diphenhydramine or diphenmax or diphenyl or diphergan or diprazin or dormarex or dytan or dytuss or eldadryl or Fargan or Farganesse or genahist or hydramine or hyrexin or isopromethazine or Lergigan or medinex or nervine or nightcalm or nu‐med or nytol or pardryl or paxidorm or pediacare or pentazine or phenadoz or phenazine or phendry or phenergan or phenerzine or phenoject or phensedyl or phenylbenzene or pipolphen or pro‐med or proazamine or progan or promacot or promet or prometazin or promethegan or prorex or prothazin or Prothiazine or provigan or pyrethia or quenalin or remsed or Romergan or Receptozine or rumergan or siladryl or siladyl or silphen or sleep tab* or sleep‐ettes or sleep‐eze or sleepia or sleepinal or sominex or somnicaps or trux‐adryl or tusstat or twilite or uni‐hist or uni‐tann or unisom sleepgels or unisom sleepmelts or valu‐dryl or wehdryl or zipan).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

34. exp Serotonin Antagonists/

35. (serotonin adj2 antagonist$).tw.

36. (dolasetron or anzemet).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

37. (granisetron or granisol or kytril or sancuso).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

38. (Ondansetron or zensana or zofran).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

39. (tropisetron or Navoban or Setrovel).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

40. exp Cholinergic Antagonists/ or anticholinergic agent$.tw.

41. (scopolamine or atrochin or boroscopol or buscapine or buscolysin or buscopan or butylscopolamine or butylscopolammonium bromide or epoxytropine tropate or hyocine hydrobromide or hyoscinbutylbromide or hyoscine or kwell or levo‐duboisine or maldemar or scoburen or scopace or scopoderm or scopolaminebutylbromide or scopolaminum hydrobromicum or scopolan or transderm or transderm‐scop or travacalm or vorigeno).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

42. exp Histamine Antagonists/

43. buclizine.tw.

44. cyclizine.tw.

45. (dimenhydrinate or antimo or aviomarin or biodramina or cinfamar or contramareo or dimen heumann or dimen lichtenstein or dimetabs or dinate or diphenhydramine theoclate or dramamine or dramin or Driminate or dramanate or dramoject or dymenate or gravol or Gravamin or marmine or nausicalm or reisegold or reisetabletten ratiopharm or reisetabletten stada or rodovan or rubiemen or superpep or travel‐eze or travel‐wise or triptone or uni‐calm or Vertirosan or Viabom or vomex or vomacur or vomisin or wehamine).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

46. (Trimethobenzamide or barogan or benzacot or tebamide or ticon or tigan).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

47. (meclizine or agyrax or antivert or bonamine or bonikraft or bonine or chiclida or histametizyn or meclicot or meclozine or medivert or parachloramine or ruvertm or univert).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

48. exp Benzodiazepines/

49. (lorazepam or almazine or apolorazepam or ativan or donix or durazolam or idalprem or laubeel or lorazep or novolorazem or nuloraz or orfidal wyeth or sedicepan or sinestron or somagerol or tolid or temesta).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

50. exp Adrenal Cortex Hormones/ or corticosteroids.tw.

51. (dexamethasone or aacidexam or adexone or adrenocot or aeroseb or aknichthol dexa or alba‐dex or alin or ambene or amplidermis or anemul mono or antimicotico or aquapred or auricularum or auxiloson or azona or baycadron or baycuten or cebedex or corson or cortastat or cortidex or cortidexason or cortisumman or corto‐tavegil or dalalone or deca or decacort or decaderm or decadron or decalix or decasone or decaspray or dectancyl or deenar or dekasol or deronil or desamethasone or desameton or dexa‐mamallet or dexa‐rhinosan or dexa‐scheroson or dexa‐sine or dexacen or dexacort phosphate or dexacort* or dexafarma or dexafluorene or dexair or dexaject or dexalocal or dexamecortin or dexameth or dexamethasonedisodium phosphate or dexamethasonum or dexamonozon or dexapos or dexasol or dexasone or dexinoral or dexium or dexpak or dinormon or doxiproct or fluorodelta or fortecortin or gammacorten or hexadecadrol or hexadrol or lokalison or loverine or maxidex or medidex or metazone or methylfluorprednisolone or millicorten or mymethasone or ocasa or ocu‐dex or oradexon or orgadrone or otomize or ozurdex or predni or primethasone or robadex or soludecadron or solurex or spersadex or trabit or visumetazone or voren).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

52. (methylprednisolone or a‐methapred or adlone or ak‐pred or ak‐tate or aprednislon or articulose or asmacortone or balpred or blephamide liquifilm or bubbli‐pred or caberdelta or capsoid or codelson or cortalone or corti‐clyss or cortimed or cortisolone or cotolone or cryosolona or decaprednil or decortin or delta‐cortef or delta‐diona or delta‐phoricol or deltacortilen or deltacortril or deltahydrocortisone or deltasolone or deltastab or deltidrosol or depmedalone or depo moderin or depo‐medrol or depo‐nisolone or depoject or depopred or dhasolone or di‐adreson‐f or diopred or dontisolon or duralone or duro cort or econopred or emmetipi or esametone or estilsona or firmacort or fisopred or flo‐pred or frisolona or gupisone or hexacortone or hostacortin or hydeltra or hydeltrasol or hydrocortancyl or inf‐oph or inflamase or inflanefran or isolone or key‐pred or klismacort or kuhlprednon or lenisolone or lepi‐cortinolo or locaseptil or longiprednil or med‐jec or medicort or medlone or medrate or medrol or medrone or mega‐star or meprdl or meprolone or metacortandralone or methacort or methylcotol or methylcotolone or methylone or methylpred or methylprednisolonum or meti derm or meticortelone or metilbetasone solubile or metipred or metrocort or metypresol or metysolon or millipred or ocu‐pred or omnipred or ophtho‐tate or opredsone or orapred or panafcortelone or pediapred or poly‐pred liquifilm or polypred or precortalon aquosum or precortisyl or pred‐clysma or pred‐ject or pred‐phosphate or predacorten or predair or predaject or predalone or predate or predcor or predeltilone or predenema or predfoam or predicort or predmix or prednabene or prednefrin or predni‐coelin or predni or predni‐helvacort or predni‐m‐tablinen or predni‐pos or prednicortelone or prednihexal or prednilen or predniocil or prednisol or prednisolone or prednoral or predonine or predsol or prelone or pri‐cortin or pri‐methylate or pricortin or radilem or sano‐drol or scherisolone‐kristall or sieropresol or solpredone or solu moderin or solu‐medrol or sterane or stintisone or summicort or urbason or urbasonsoluble or veripred or wyacort).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

53. exp cannabinoids/

54. cannabinoid$.tw.

55. (cannador or charas or ganja* or hashish or hemp or cannabis or marihuana or marijuana).tw.

56. (marinol or dronabinol or tetrahydrocannabinol).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

57. or/24‐56

58. exp infant/ or infan$.tw.

59. exp child/ or child$.tw.

60. exp Child, Preschool/

61. neonat$.tw.

62. pediatric$.mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

63. paediatric$.mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier]

64. juvenile$.tw.

65. exp adolescent/ or adolescen$.tw.

66. or/58‐65

67. 23 and 57 and 66

68. 11 and 67

69. limit 68 to ed=20080515‐20100704

Updated strategy, run July 2010

1. exp randomized controlled trial/ 2. randomized controlled trial$.tw. 3. exp randomization/ 4. exp single blind procedure/ 5. exp double blind procedure/ 6. or/1‐5 7. animal.hw. 8. human.hw. 9. 7 not (7 and 8) 10. 6 not 9 11. exp clinical trial/ 12. (clin$ adj3 (stud$ or trial$)).ti,ab,tw. 13. (clin$ adj3 trial$).ti,ab,tw. 14. ((singl$ or doubl$ or treb$ or tripl$) adj3 (blind$ or mask$)).ti,ab,tw. 15. exp placebo/ 16. placebo$.ti,ab,tw. 17. random.ti,ab,tw. 18. (crossover$ or cross‐over$).ti,ab,tw. 19. or/11‐18 20. 19 not 9 21. 20 not 10 22. exp comparative study/ 23. exp evaluation/ 24. exp prospective study/ 25. exp controlled study/ 26. (control$ or prospective$ or volunteer$).ti,ab,tw. 27. or/22‐26 28. 27 not 9 29. 10 or 21 or 28 30. exp gastroenteritis/ 31. gastroenteritis.tw. 32. exp virus infection/ or rotavirus infection$.tw.

33. exp norwalk gastroenteritis virus/ or norwalk virus.tw.

34. exp vomiting/

35. vomit$.tw.

36. exp infantile diarrhea/

37. diarrhea.tw.

38. diarrhoea.tw.

39. exp dehydration/

40. dehydrat$.tw.

41. or/30‐40

42. exp antiemetic agent/ or antiemetic$.tw.

43. exp dopamine receptor blocking agent/

44. (dopamin$ adj2 antagonists).tw.

45. (Chlorpromazine or aminazine or chloractil or chlordelazine or contomin or dozine or fenactil or largactil or ormazine or propaphenin or thorazine).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

46. (droperidol or dehidrobenzperidol or droleptan or inapsine or Dridol).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

47. (domperidon$ or domidon or evoxin or gastrocure or motilium or motillium or motinorm or costi or nauzelin).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

48. (metoclopramide or cerucal or clopra or degan or gastrese or gastrobid continus or gastroflux or gastromax or maxolon or maxeran or metaclopramide or metozolv or metramid or migravess or mygdalon or octamide or parmid or primperan or pylomid or reglan or reliveran or rimetin).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

49. (haloperidol or dozic or Aloperidin or Bioperidolo or Brotopon Duraperidol or fortunan or haldol or kentace or Einalon or Eukystol, or Halosten or Keselan or Linton or Peluces or Serenase or Sigaperidol or serenace).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

50. (prochlorperazine or buccastem or compazine or compro or emezine or procot or proziere or Phenotil or stemetil or Stemzine).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

51. (promethazine or Avomine or adgan or aler‐dryl or aler‐tab or aller‐dryl topical or allergia or allermax or altaryl or anergan or antihist or antinaus or antituss or atosil or banaril or banophen or beldin or belix or ben tann or benadryl or benahist or bendylate or benekraft or benzhydramine or bromanate or calm‐aid or derma‐pax or dimedrol or dimine or diphen or diphenadryl or diphenhist or diphenhydramine or diphenmax or diphenyl or diphergan or diprazin or dormarex or dytan or dytuss or eldadryl or Fargan or Farganesse or genahist or hydramine or hyrexin or isopromethazine or Lergigan or medinex or nervine or nightcalm or nu‐med or nytol or pardryl or paxidorm or pediacare or pentazine or phenadoz or phenazine or phendry or phenergan or phenerzine or phenoject or phensedyl or phenylbenzene or pipolphen or pro‐med or proazamine or progan or promacot or promet or prometazin or promethegan or prorex or prothazin or Prothiazine or provigan or pyrethia or quenalin or remsed or Romergan or Receptozine or rumergan or siladryl or siladyl or silphen or sleep tab* or sleep‐ettes or sleep‐eze or sleepia or sleepinal or sominex or somnicaps or trux‐adryl or tusstat or twilite or uni‐hist or uni‐tann or unisom sleepgels or unisom sleepmelts or valu‐dryl or wehdryl or zipan).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

52. exp serotonin antagonist/

53. (serotonin adj2 antagonist$).tw.

54. (dolasetron or anzemet).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

55. (granisetron or granisol or kytril or sancuso).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

56. (Ondansetron or zensana or zofran).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

57. (tropisetron or Navoban or Setrovel).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

58. exp cholinergic receptor blocking agent/ or anticholinergic agent$.tw.

59. (scopolamine or atrochin or boroscopol or buscapine or buscolysin or buscopan or butylscopolamine or butylscopolammonium bromide or epoxytropine tropate or hyocine hydrobromide or hyoscinbutylbromide or hyoscine or kwell or levo‐duboisine or maldemar or scoburen or scopace or scopoderm or scopolaminebutylbromide or scopolaminum hydrobromicum or scopolan or transderm or transderm‐scop or travacalm or vorigeno).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

60. exp antihistaminic agent/

61. buclizine.tw.

62. cyclizine.tw.

63. (dimenhydrinate or antimo or aviomarin or biodramina or cinfamar or contramareo or dimen heumann or dimen lichtenstein or dimetabs or dinate or diphenhydramine theoclate or dramamine or dramin or Driminate or dramanate or dramoject or dymenate or gravol or Gravamin or marmine or nausicalm or reisegold or reisetabletten ratiopharm or reisetabletten stada or rodovan or rubiemen or superpep or travel‐eze or travel‐wise or triptone or uni‐calm or Vertirosan or Viabom or vomex or vomacur or vomisin or wehamine).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

64. (Trimethobenzamide or barogan or benzacot or tebamide or ticon or tigan).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

65. (meclizine or agyrax or antivert or bonamine or bonikraft or bonine or chiclida or histametizyn or meclicot or meclozine or medivert or parachloramine or ruvertm or univert).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

66. exp benzodiazepine derivative/

67. (lorazepam or almazine or apolorazepam or ativan or donix or durazolam or idalprem or laubeel or lorazep or novolorazem or nuloraz or orfidal wyeth or sedicepan or sinestron or somagerol or tolid or temesta).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

68. exp corticosteroid/

69. (dexamethasone or aacidexam or adexone or adrenocot or aeroseb or aknichthol dexa or alba‐dex or alin or ambene or amplidermis or anemul mono or antimicotico or aquapred or auricularum or auxiloson or azona or baycadron or baycuten or cebedex or corson or cortastat or cortidex or cortidexason or cortisumman or corto‐tavegil or dalalone or deca or decacort or decaderm or decadron or decalix or decasone or decaspray or dectancyl or deenar or dekasol or deronil or desamethasone or desameton or dexa‐mamallet or dexa‐rhinosan or dexa‐scheroson or dexa‐sine or dexacen or dexacort phosphate or dexacort* or dexafarma or dexafluorene or dexair or dexaject or dexalocal or dexamecortin or dexameth or dexamethasonedisodium phosphate or dexamethasonum or dexamonozon or dexapos or dexasol or dexasone or dexinoral or dexium or dexpak or dinormon or doxiproct or fluorodelta or fortecortin or gammacorten or hexadecadrol or hexadrol or lokalison or loverine or maxidex or medidex or metazone or methylfluorprednisolone or millicorten or mymethasone or ocasa or ocu‐dex or oradexon or orgadrone or otomize or ozurdex or predni or primethasone or robadex or soludecadron or solurex or spersadex or trabit or visumetazone or voren).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

70. (methylprednisolone or a‐methapred or adlone or ak‐pred or ak‐tate or aprednislon or articulose or asmacortone or balpred or blephamide liquifilm or bubbli‐pred or caberdelta or capsoid or codelson or cortalone or corti‐clyss or cortimed or cortisolone or cotolone or cryosolona or decaprednil or decortin or delta‐cortef or delta‐diona or delta‐phoricol or deltacortilen or deltacortril or deltahydrocortisone or deltasolone or deltastab or deltidrosol or depmedalone or depo moderin or depo‐medrol or depo‐nisolone or depoject or depopred or dhasolone or di‐adreson‐f or diopred or dontisolon or duralone or duro cort or econopred or emmetipi or esametone or estilsona or firmacort or fisopred or flo‐pred or frisolona or gupisone or hexacortone or hostacortin or hydeltra or hydeltrasol or hydrocortancyl or inf‐oph or inflamase or inflanefran or isolone or key‐pred or klismacort or kuhlprednon or lenisolone or lepi‐cortinolo or locaseptil or longiprednil or med‐jec or medicort or medlone or medrate or medrol or medrone or mega‐star or meprdl or meprolone or metacortandralone or methacort or methylcotol or methylcotolone or methylone or methylpred or methylprednisolonum or meti derm or meticortelone or metilbetasone solubile or metipred or metrocort or metypresol or metysolon or millipred or ocu‐pred or omnipred or ophtho‐tate or opredsone or orapred or panafcortelone or pediapred or poly‐pred liquifilm or polypred or precortalon aquosum or precortisyl or pred‐clysma or pred‐ject or pred‐phosphate or predacorten or predair or predaject or predalone or predate or predcor or predeltilone or predenema or predfoam or predicort or predmix or prednabene or prednefrin or predni‐coelin or predni or predni‐helvacort or predni‐m‐tablinen or predni‐pos or prednicortelone or prednihexal or prednilen or predniocil or prednisol or prednisolone or prednoral or predonine or predsol or prelone or pri‐cortin or pri‐methylate or pricortin or radilem or sano‐drol or scherisolone‐kristall or sieropresol or solpredone or solu moderin or solu‐medrol or sterane or stintisone or summicort or urbason or urbasonsoluble or veripred or wyacort).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

71. exp cannabinoid/

72. cannabinoid$.tw.

73. (cannador or charas or ganja* or hashish or hemp or cannabis or marihuana or marijuana).tw.

74. (marinol or dronabinol or tetrahydrocannabinol).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name]

75. or/42‐74

76. exp infant/ or infan$.tw.

77. exp child/ or child$.tw.

78. neonat$.tw.

79. exp pediatrics/ or pediatric$.tw.

80. paediatric$.tw.

81. exp juvenile/ or juvenile$.tw. or exp adolescent/

82. or/76‐81

83. 41 and 75 and 82

84. 29 and 83

85. chemotherapy.ti.

86. operat$.ti.

87. surg$.ti.

88. strab$.ti.

89. tonsil$.ti.

90. anesth$.ti.

91. migraine.ti.

92. colitis.ti.

93. crohn$.ti.

94. or/85‐93

95. 84 not 94

96. limit 95 to (editorial or letter or note or "review" or short survey)

97. 95 not 96

98. limit 97 to em=200824‐201028

Page 2

Oral ondansetron (weight based) compared to placebo for vomiting related to acute gastroenteritis in children