Introduction: Recent evidence suggests that assisted reproductive technology (ART) increases the risk of adverse pregnancy outcomes, including placental disorders. Similarly, endometriosis resulted detrimental on placenta previa. However, up to 50% of women with endometriosis suffer from infertility, thus requiring ART. The aim of our metanalysis is to compare women with and without endometriosis undergoing ART in terms of placenta disorders events, to establish if ART itself or endometriosis, as an indication to ART, increases the risk of placenta previa. Methods: Literature searches were conducted in January 2018 using electronic databases (PubMed, Medline, Scopus, Embase, Science Direct, and the Cochrane Library Scopus). Series comparing pregnancy outcome after ART in women with and without endometriosis were screened and data on placenta previa and placental abruption were extracted. Results: Five retrospective case-control studies met the inclusion criteria. The meta-analysis revealed that endometriosis is associated with an increased risk of placenta previa in pregnancies achieved through ART (OR 2.96 (95% CI 1.25-7.03); p = 0.01, I2 =69%, random-effect model). No differences in placental abruption incidence were found (OR 0.44 (95% CI 0.10-1.87); p = 0.26, I2 = 0%, fixed-effect model). Conclusion: Patients with endometriosis undergoing ART may have additional risk of placenta previa. Despite the inability to determine if endometriosis alone or endometriosis plus ART increase the risk, physicians should be aware of the potential additional risk that endometriosis patients undergoing ART harbor. Keywords: Adverse pregnancy outcome; Assisted reproduction; Endometriosis; Placenta previa; Placental abruption. Placental abruption is the early separation of the placenta from the lining of the uterus before the completion of the second stage of labor. It is one of the causes of bleeding during the second half of pregnancy and is a relatively rare but serious complication of pregnancy that places the well-being of both mother and fetus at risk. This activity describes the pathophysiology of placental abruption and highlights the role of the interprofessional team in managing affected patients. Objectives:
Placental abruption is the early separation of a placenta from the lining of the uterus before completion of the second stage of labor. It is one of the causes of bleeding during the second half of pregnancy. Placental abruption is a relatively rare but serious complication of pregnancy and placed the well-being of both mother and fetus at risk. Placental abruption is also called abruptio placentae.[1][2] The exact etiology of placental abruption is unknown. However, a number of factors are associated with its occurrence. Risk factors can be thought of in 3 groups: health history, including behaviors, and past obstetrical events, current pregnancy, and unexpected trauma. Factors that can be identified during the health history that increase the risk of placental abruption include smoking, cocaine use during pregnancy, maternal age over 35 years, hypertension, and placental abruption in a prior pregnancy. Conditions specific to the current pregnancy which may precipitate placental abruption are multiple gestation pregnancies, polyhydramnios, preeclampsia, sudden uterine decompression, and short umbilical cord. Finally, trauma to the abdomen such as a motor vehicle accident, fall, or violence resulting in a blow to the abdomen may lead to placental abruption. Placental abruption occurs when there is a compromise of the vascular structures supporting the placenta. In other words, the vascular networks connecting the uterine lining and the maternal side of the placenta are torn away. These vascular structures deliver oxygen and nutrients to the fetus. Disruption of the vascular network may occur when the vascular structures are compromised because of hypertension or substance use or by conditions that cause stretching of the uterus. The uterus is a muscle and is elastic whereas the placenta is less elastic than the uterus. Therefore, when the uterine tissue stretches suddenly, the placenta remains stable and the vascular structure connecting the uterine wall to the placenta tear away.[3][4] Placental abruption is a relatively rare condition but requires emergent management. The majority of placental abruptions occur before 37-weeks gestation. Placental abruption is a leading cause of maternal morbidity and perinatal mortality. With placental abruption, the woman is at risk for hemorrhage and the need for blood transfusions, hysterectomy, bleeding disorders specifically disseminated intravascular coagulopathy, renal failure, and Sheehan syndrome or postpartum pituitary gland necrosis. With the availability of blood replacement, maternal death is rare but continues to be higher than the overall maternal mortality rate. Neonatal consequences include preterm birth and low birth weight, perinatal asphyxia, stillbirth, and neonatal death. In many countries, the rate of placental abruption has been increasing, even with improved obstetrical care and monitoring techniques. This suggests a multifactorial etiology that is not well understood.[5][3] Placental abruption occurs when the maternal vessels tear away from the placenta and bleeding occurs between the uterine lining and the maternal side of the placenta. As the blood accumulates, it pushes the uterine wall and placenta apart. The placenta is the fetus’ source of oxygen and nutrients as well as the way the fetus excretes waste products. Diffusion to and from the maternal circulatory system is essential to maintaining these life-sustaining functions of the placenta. When accumulating blood causes separation of the placenta from the maternal vascular network, these vital functions of the placenta are interrupted. If the fetus does not receive enough oxygen and nutrients, it dies.[6][7] The clinical implications of a placental abruption vary based on the extent of the separation and the location of the separation. Placental abruption can be complete or partial and marginal or central. The classification of placental abruption is based on the following clinical findings: Class 0: Asymptomatic
Class 1: Mild
Class 2: Moderate
Class 3: Severe
Classification of 0 or 1 is usually associated with a partial, marginal separation; whereas, classification of 2 or 3 is associated with complete or central separation. Once the placenta has been delivered, the presence of a retroplacental clot is almost always seen. In some cases, there may be evidence of blood extravasation into the myometrium- resulting in purple discoloration of the serosa of the uterus. Placental abruption is one of the causes of vaginal bleeding in the second half of pregnancy. A focused history and physical is critical to differentiate placental abruption and other causes of vaginal bleeding. Because a definitive diagnosis of placental abruption can only be made after birth when the placenta is examined the history and physical examination are critical to the appropriate management of the maternal/fetal dyad. Placental abruption is a potentially life-threatening situation. Therefore, accurate assessment of the patient is critical to developing an appropriate management plan and to prevent a potentially poor outcome. The history begins with a review of the prenatal course, especially placental location on prior sonograms and if there is a history of placental abruption in previous pregnancies. Exploring the woman’s behaviors, specifically whether she smokes or uses cocaine is a critical component of history. Asking about potential trauma, especially in the abdominal area needs to be done in a tactful and supportive manner. Especially in situations of partner abuse, the woman may be reluctant to reveal that she sustained trauma to her abdomen. The most useful mechanism for recognizing the onset of placental abruption is an assessment of the patient. The physical examination includes palpation of the uterus. The uterus is palpated for tenderness, consistency, and frequency and duration of uterine contractions, if present. The vaginal area is inspected for the presence of bleeding. However, a digital examination of the cervix should be delayed until a sonogram is obtained for placental location and to rule out a placenta previa. If bleeding is present, the quantity and characteristic of the blood, as well as the presence of clots, is evaluated. Remember, the absence of vaginal bleeding does not eliminate the diagnosis of placental abruption. Evaluation of vital signs to detect tachycardia or hypotension, which may be indicators of a concealed hemorrhage are taken. Blood specimens such as a complete blood count (CBC), fibrinogen, clotting profile, and type and RH may be collected. These laboratory values will not aid in the diagnosis of placental abruption but will provide baseline data against which to evaluate the patient’s condition over time. Evaluation of fetal well-being is also included in the examination. Begin with auscultation of fetal heart sounds and ask about fetal movement, specifically recent changes in activity patterns. Continuous electronic fetal monitoring is initiated to identify prolonged bradycardia, decreased variability, and the presence of late decelerations. There are no laboratory tests or diagnostic procedures to definitively diagnose placental abruption. However, some studies may be conducted in the effort to eliminate other conditions as well as to provide baseline data.[8][9][10] An ultrasound examination is useful in determining the placental location and eliminating the diagnosis of placenta previa. However, the sensitivity of ultrasound in visualizing placental abruption is low. During the acute phase of placental abruption, the hemorrhage is isoechoic or similar to the surrounding placental tissue. Therefore, visualization and differentiation of the concealed hemorrhage associated with placental abruption from the surrounding placental tissue are difficult. A biophysical profile may be used in the management of patients with marginal placental abruption who are being conservatively treated. A score of 6 or below is an indicator of compromised fetal status. Blood work, including a CBC, clotting studies (fibrinogen and PT/a-PTT), and BUN provide baseline parameters to evaluate changes in the patient’s status. A type and Rh have been obtained if a blood transfusion is necessary. A Kleihauer-Betke test, which detects fetal blood cells in maternal circulation may be ordered. A Kleihauer-Betke test does not diagnose the presence of placental abruption but quantifies the presence of fetal blood into the maternal circulation. This knowledge is important in women who are Rh-negative, because the mixing of fetal blood in the maternal circulation may lead to isoimmunization. Therefore, if a significant fetal-maternal bleed is present, the Kleihauer-Betke test results will help to determine the needed dose of Rh (D) immune globulin to prevent isoimmunization. The onset of placental abruption is often unexpected, sudden, and intense and requires immediate treatment. Prehospital care for the patient with a suspected placental abruption requires advanced life support and transport to a hospital with a full-service obstetrical unit and a neonatal intensive care unit. Following arrival at the hospital, most women will receive intravenous (IV) fluids and supplemental oxygen as well as continuous maternal and fetal monitoring, while the history and physical is completed. Subsequent treatment will vary based on the data collected during the assessment, the gestation of the pregnancy, and the degree of distress being experienced by the woman and/or the fetus.[11][12] Women classified with a class 1 or mild placental abruption and no signs of maternal or fetal distress and pregnancy less than 37 weeks gestation may be managed conservatively. These patients are usually admitted to the obstetrical unit for close monitoring of maternal and fetus status. Intravenous access and blood work for type and cross-match is part of the plan of care. The maternal-fetal dyad will continue to be monitored until there is a change in condition or until fetal maturity is reached. If the collected data results in class 2 (moderate) or class 3 (severe) classification and the fetus is viable and alive, delivery is necessary. Because of the hypertonic contractions, a vaginal birth may occur rapidly. Given the potential for coagulopathy, vaginal birth presents less risk to the mother. However, if there are signs of fetal distress an emergency cesarean birth is necessary to protect the fetus. During the surgical procedure, careful management of fluids and circulatory volume is important. Post-operatively the patient needs to be monitored for postpartum hemorrhage and alterations in the clotting profile. A neonatal team needs to be present in the delivery room to receive and manage the infant. Bleeding during the second half of pregnancy is usually due to either placental abruption or placenta previa. Differentiating these 2 conditions is important to the care of the patient. The information below compares the presentation of placental abruption and placenta previa on common parameters included in an obstetrical examination.
The prognosis depends on when the patient presents to the hospital. If the bleeding continues, both maternal and fetal lives are at stake. Partial placenta separation is associated with low mortality compared to full separation; however in both cases, without an emergent cesarean section, fetal demise may occur. Today, the condition accounts for 5 to 8% of maternal deaths. Complications
Placental abruption is a serious complication of pregnancy and is best managed by an interprofessional team of healthcare professionals that include an obstetrician, radiologist, hematologist, obstetric nurse, and intensivist. The triage nurse should be aware of this condition and immediately admit and notify the emergency department physician. While the patient is being resuscitated, the obstetrician should be called ASAP. Immediate transfer to an ICU setting is highly recommended and blood should be crossed and typed in case needed. Placental abruption is a true obstetric emergency and requires collaboration between the anesthesiologist and a radiologist. Operating room nurses should be informed of the patient so that they have the room prepared. In case the fetus is premature, the neonatal ICU team should be notified. Only with a team approach can the morbidity and mortality of this disorder be lowered. While the condition cannot be prevented, the patient must be encouraged to stop smoking to lower the risk. Another major risk factor is the abuse of cocaine, which must be curtailed. Some patients may benefit from drug counseling and or drug rehabilitation.[13][14] [Level 5] Outcomes Placental abruption is a life-threatening disorder for both the mother and the fetus. If the bleeding is not arrested, then the lives of the mother and fetus are in jeopardy. If there is complete separation or near separation of the placenta, death is inevitable, unless an immediate cesarean section is performed. Fetal mortality rates of 1-40% have been reported, but this also depends on the age of the fetus and the extent of separation. Each year in the US, about 1 to 5% of maternal deaths are linked to placental abruption. Besides the hemorrhage, the other morbidity is related to blood transfusions, the prematurity of the fetus, hysterectomy, and cesarean section (which will make the need for future cesarean sections more likely). Recurrence rates of 3-10% are reported. [2][15] [Level 5] Review Questions Illustration of placental abruption. Marginal separation, partial separation, complete separation with concealed hemorrhage. Cervical bleeding. Contributed by Chelsea Rowe 1. Workalemahu T, Enquobahrie DA, Gelaye B, Thornton TA, Tekola-Ayele F, Sanchez SE, Garcia PJ, Palomino HG, Hajat A, Romero R, Ananth CV, Williams MA. Abruptio placentae risk and genetic variations in mitochondrial biogenesis and oxidative phosphorylation: replication of a candidate gene association study. Am J Obstet Gynecol. 2018 Dec;219(6):617.e1-617.e17. [PMC free article: PMC6497388] [PubMed: 30194050] 2.Martinelli KG, Garcia ÉM, Santos Neto ETD, Gama SGND. Advanced maternal age and its association with placenta praevia and placental abruption: a meta-analysis. Cad Saude Publica. 2018 Feb 19;34(2):e00206116. [PubMed: 29489954] 3.Workalemahu T, Enquobahrie DA, Gelaye B, Sanchez SE, Garcia PJ, Tekola-Ayele F, Hajat A, Thornton TA, Ananth CV, Williams MA. Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies. Placenta. 2018 Jun;66:8-16. [PMC free article: PMC5995331] [PubMed: 29884306] 4.Sylvester HC, Stringer M. Placental abruption leading to hysterectomy. BMJ Case Rep. 2017 Dec 11;2017 [PMC free article: PMC5728244] [PubMed: 29233830] 5.Miller C, Grynspan D, Gaudet L, Ferretti E, Lawrence S, Moretti F, Lafreniere A, McGee A, Lattuca S, Black A. Maternal and neonatal characteristics of a Canadian urban cohort receiving treatment for opioid use disorder during pregnancy. J Dev Orig Health Dis. 2019 Feb;10(1):132-137. [PubMed: 30113278] 6.Plowman RS, Javidan-Nejad C, Raptis CA, Katz DS, Mellnick VM, Bhalla S, Cornejo P, Menias CO. Imaging of Pregnancy-related Vascular Complications. Radiographics. 2017 Jul-Aug;37(4):1270-1289. [PubMed: 28696852] 7.DeRoo L, Skjærven R, Wilcox A, Klungsøyr K, Wikström AK, Morken NH, Cnattingius S. Placental abruption and long-term maternal cardiovascular disease mortality: a population-based registry study in Norway and Sweden. Eur J Epidemiol. 2016 May;31(5):501-11. [PMC free article: PMC4901083] [PubMed: 26177801] 8.Ananth CV, Wapner RJ, Ananth S, D'Alton ME, Vintzileos AM. First-Trimester and Second-Trimester Maternal Serum Biomarkers as Predictors of Placental Abruption. Obstet Gynecol. 2017 Mar;129(3):465-472. [PMC free article: PMC5367463] [PubMed: 28178056] 9.Arlier S, Adiguzel C, Yilmaz ES, Seyfettinoglu S, Helvacioglu C, Ekin GU, Nazik H, Yucel O. The role of mean platelet volume and platelet distribution width in the prediction of placental abruption. J Obstet Gynaecol. 2016 Oct;36(7):950-953. [PubMed: 27184035] 10.Saphier NB, Kopelman TR. Traumatic Abruptio Placenta Scale (TAPS): a proposed grading system of computed tomography evaluation of placental abruption in the trauma patient. Emerg Radiol. 2014 Feb;21(1):17-22. [PubMed: 24057218] 11.Society for Maternal-Fetal Medicine (SMFM). Electronic address: . Gyamfi-Bannerman C. Society for Maternal-Fetal Medicine (SMFM) Consult Series #44: Management of bleeding in the late preterm period. Am J Obstet Gynecol. 2018 Jan;218(1):B2-B8. [PubMed: 29079144] 12.Downes KL, Grantz KL, Shenassa ED. Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review. Am J Perinatol. 2017 Aug;34(10):935-957. [PMC free article: PMC5683164] [PubMed: 28329897] 13.Boisramé T, Sananès N, Fritz G, Boudier E, Aissi G, Favre R, Langer B. Placental abruption: risk factors, management and maternal-fetal prognosis. Cohort study over 10 years. Eur J Obstet Gynecol Reprod Biol. 2014 Aug;179:100-4. [PubMed: 24965988] 14.Rhodes AM. Malpractice suits: implications for obstetric nurses. MCN Am J Matern Child Nurs. 1986 May-Jun;11(3):203. [PubMed: 3088363] 15.Downes KL, Shenassa ED, Grantz KL. Neonatal Outcomes Associated With Placental Abruption. Am J Epidemiol. 2017 Dec 15;186(12):1319-1328. [PMC free article: PMC5860509] [PubMed: 28595292] |
What is the difference in patient presentation between a placenta previa and a placental abruption?
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